American Airlines offers various mainline routes from John Glenn Columbus International Airport in Columbus, Ohio, to key destinations across the United States and beyond. These routes and their frequencies ensure ample capacity for both business and leisure travelers.

Let’s take a closer look at each destination that American Airlines connects to from Columbus, Ohio – from most to least served – and explore the operational specifics of these routes, including frequency, available seating, and more. The data in this article is valid for November 2024, and is sourced from Cirium, an aviation analytics company.

American Airlines’ presence in Columbus, Ohio

American Airlines has a strong and well-established presence at John Glenn Columbus International Airport (CMH), offering a variety of mainline routes that connect the city to major domestic and international destinations.

An American Airlines plane at John Glenn Columbus International Airport (CMH)

Photo: John Glenn Columbus International Airport (CMH) 

As one of the largest carriers operating out of CMH, American Airlines provides extensive connectivity for both business and leisure travelers. The airline operates frequent flights to major hubs, making it easier for passengers to access onward connections across the US and beyond.

In addition to domestic routes, American Airlines also offers seasonal international flights, providing Columbus travelers with convenient options for vacations and getaways. With its large capacity and regular operations, American Airlines plays a crucial role in ensuring Columbus remains a well-connected city in the airline’s broader network. It’s worth noting that the airline’s true presence at CMH is larger than presented here, thanks to flights operated by its regional branch, American Eagle, and other regional partners.

Charlotte, North Carolina (CLT)

Charlotte Douglas International Airport is a major hub for American Airlines, serving as a key connection point for domestic and international travelers. The CMH-CLT route is heavily trafficked, providing seamless connections to a wide range of destinations across the globe.

American Airlines Airbus A321 taking off with Boeing 737-823 in the background at Charlotte Douglas International Airport FI

Photo: Charlotte Douglas International Airport

Route details for November 2024:

  • Route distance: 346 miles (557 km)
  • Number of flights: 105
  • Total seats: 14,232
  • Seats per departure: 135.5
  • Available Seat Miles (ASMs): 4,924,272

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With over 100 operations in a month – representing American Airlines’ most frequently served mainline route from CMH in November 2024 – the Columbus to Charlotte route offers extensive connectivity for both business and vacation travelers.

Dallas/Fort Worth, Texas (DFW)

American Airlines operates a substantial number of flights from Columbus to Dallas/Fort Worth International Airport, its largest hub. This route connects Ohio travelers to American Airlines’ vast network in the southwestern US and beyond, including destinations in Latin America and Asia.

American Airlines Airbus A321 landing at Dallas Fort Worth International Airport DFW

Photo: Markus Mainka | Shutterstock

Route details for November 2024:

  • Route distance: 927 miles (1,492 km)
  • Number of flights: 87
  • Total seats: 14,964
  • Seats per departure: 172.0
  • ASMs: 13,871,628

Dallas/Fort Worth’s strategic location ensures that passengers can easily access numerous onward connections while traveling through one of the busiest hubs in the US.

Phoenix, Arizona (PHX)

Phoenix Sky Harbor International Airport is a key hub for American Airlines in the western US. The Columbus to Phoenix route offers direct access to this sun-soaked city, making it ideal for travelers heading to Arizona or beyond to other destinations in the western US or Mexico.

American Airlines at PHX airport

Photo: Markus Mainka | Shutterstock

Route details for November 2024:

  • Route distance: 1,671 miles (2,689 km)
  • Number of flights: 46
  • Total seats: 6,548
  • Seats per departure: 142.3
  • ASMs: 10,941,708

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This long-distance route is especially popular during the winter months when travelers seek out warmer climates. Additionally, Phoenix serves as a gateway for connecting to other southwestern cities and even Hawaii.

Philadelphia, Pennsylvania (PHL)

Philadelphia International Airport is another important hub for American Airlines, offering travelers from Columbus easy access to the East Coast and Europe. The CMH-PHL route is well-served, ensuring connectivity for both leisure and business travel.

American Airlines aircraft at Philadelphia International Airport PHL shutterstock_1373834117

Photo: EQRoy | Shutterstock

Route details for November 2024:

  • Route distance: 405 miles (652 km)
  • Number of flights: 28
  • Total seats: 3,584
  • Seats per departure: 128.0
  • ASMs: 1,451,520

Although the frequency of flights between Columbus and Philadelphia is lower compared to other routes, the convenient schedule still allows travelers to reach their destination with ease.

Cancun, Mexico (CUN)

For those seeking international travel, American Airlines offers flights from Columbus to Cancun, a popular vacation destination. This seasonal service helps travelers easily escape Ohio’s cold winters to the beaches of Mexico. Although the frequency of this route is low, the flights are a great option for Ohioans looking for a quick getaway to the Yucatán Peninsula.

An American Airlines airplane taxis the runway at Cancun International Airport

Photo: Wangkun Jia | Shutterstock

Route details for November 2024:

  • Route distance: 1,327 miles (2,135 km)
  • Number of flights: 4
  • Total seats: 688
  • Seats per departure: 172.0
  • ASMs: 912,976

Chicago, Illinois (ORD)

Flying into Chicago O’Hare International Airport, American Airlines offers several direct flights from Columbus. O’Hare is one of the most crucial hubs in the Midwest, providing passengers with convenient access to the central and northern regions of the United States, along with international destinations.

American Airlines Airbus A321 (N540UW) landing at Chicago O'Hare International Airport.

Photo: MKPhoto12 | Shutterstock

Route details for November 2024:

  • Route distance: 296 miles (476 km)
  • Number of flights: 2
  • Total seats: 344
  • Seats per departure: 172.0
  • ASMs: 101,824

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Although there are only two flights from Columbus to Chicago in November, this route is vital for connecting travelers in Ohio to one of the busiest aviation markets in the world.

Final thoughts

American Airlines provides an extensive network out of John Glenn Columbus International Airport, covering key domestic and international destinations. Whether flying for business or leisure, travelers from Columbus benefit from frequent, well-serviced routes.

DSC_3149

Photo: John Glenn Columbus International Airport (CMH) 

The hub-to-hub connections provided by American Airlines make it easier for passengers to access onward international flights or explore the US in greater depth. With routes like those to Charlotte and Dallas/Fort Worth, American Airlines continues to strengthen Columbus’s connectivity to major destinations across the globe.

CMH sign - International Gateway at John Glenn Columbus International Airport

Photo: John Glenn Columbus International Airport (CMH) 

The variety of frequencies and seat configurations on these routes ensures that passengers have flexibility in their travel plans while enjoying seamless connectivity across American Airlines’ vast network.

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